Help Center
good questions.
Plain answers about the Gut Health System, membership, orders and returns. Search, or pick a topic.
- Getting startedNew to Plexus? Begin here.5 questions
- The Gut Health SystemWeed, seed and feed, and how to take them.4 questions
- Products & ingredientsCapsules, caffeine, storage and labels.9 questions
- Taking Plexus with other thingsMedication, pregnancy and allergies.4 questions
- VIP membershipWhat it costs, what it saves, renewals.3 questions
- Monthly deliverySet it up, change it or stop it.3 questions
- Orders & shippingChanges, delivery times, missing items.4 questions
- Returns & the guaranteeThe 60-day money-back guarantee.4 questions
- Brand AmbassadorsWho they are and how to join.3 questions
- Account & helpReach a real person.2 questions
getting started.
5 questions
Where do I start?
Most people start with the Gut Health System: Bio Cleanse, ProBio 5 and Slim Microbiome Activating, taken together every day. Not sure it fits? Take the routine finder, or ask your Brand Ambassador.
Who is Plexus?
Plexus Worldwide is a wellness company founded in 2008 in Scottsdale, Arizona. Founded in gut health. Experts in microbiome. Plexus makes products for gut health, weight management, an active lifestyle, general nutrition, women’s health, family and skin health, shared by independent Brand Ambassadors. Read our story.
Do I need a membership to buy?
No. You can shop as a Retail Customer at the retail price, with no fee. If you buy often, a VIP membership saves up to 25% on products that show a VIP price. See VIP membership.
Is there something for my skin?
Yes. There is the Plexus Skin Health System, and skin care you can buy on its own, including a gel cleanser, a serum, an eye cream, a night cream and a mineral sunscreen. See skin health.
Is there something for my kids?
Yes. Most Plexus products are made for adults 18 and older, so look for products made for children, like XFactor Kids, and always follow the ages and directions on the label. See family nutrition.
the gut health system.
4 questions
What is in the Gut Health System?
Three products used together as a daily routine: Bio Cleanse, ProBio 5 and Slim Microbiome Activating. Each one is also sold on its own.
What do weed, seed and feed mean?
It is how Plexus teaches the Gut Health System. Weed is Bio Cleanse, seed is ProBio 5 and feed is Slim Microbiome Activating.
How do I take the Gut Health System?
Follow the directions on each label. As part of the Gut Health System:
- Bio Cleanse. Adults take 2 capsules with 8 ounces of water twice daily between meals, in conjunction with a reduced-calorie weight loss diet plan.
- ProBio 5. Adults take 1 capsule daily at bedtime.
- Slim Microbiome Activating. Adults drink 1 serving up to twice daily. Tear the packet, pour it into a 12 to 20 ounce bottle of water and shake.
Bio Cleanse 60 or 120: what is the difference?
The Gut Health System comes in two versions, named for the size of the Bio Cleanse bottle inside: 60 capsules or 120 capsules. Each product page shows exactly what is in the box.
products & ingredients.
9 questions
Is Slim vegan and gluten free?
Yes. Slim Microbiome Activating is gluten free, vegan and non-GMO, with no artificial colors, flavors, sweeteners or preservatives. It is sweetened with stevia leaf extract and has 5 calories a serving.
Does Slim have caffeine?
It depends on the flavor. In Sweet Tea, about 25mg of caffeine comes from the black tea in the flavoring. In the other flavors, the green coffee extract is less than 2% caffeine, and Plexus says Slim is not a significant source of caffeine per serving. Check the label of your flavor, and ask your healthcare provider if caffeine is a concern.
What is in ProBio 5?
ProBio 5 has 2 billion CFU per capsule at the time of manufacture, from five probiotics: Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus plantarum, Bacillus coagulans and Saccharomyces boulardii. It also has a blend of enzymes, namely proteases, cellulase and serrapeptase, plus grape seed extract. It is non-GMO and gluten free.
What kind of capsules do you use?
Bio Cleanse uses a vegetable capsule made from hypromellose, and is vegetarian, non-GMO, soy free and gluten free. ProBio 5 uses a gelatin capsule that may be a combination of porcine and bovine materials. The gelatin is in the capsule only, not in the blend.
Can I open the capsules?
Plexus recommends taking capsules the way the label says. You can open them, but that may reduce the protection the closed capsule gives against stomach acid. That matters most for ProBio 5 and VitalBiome.
Where are Plexus products made?
All Plexus products are currently made in the USA, by manufacturers that follow the FDA’s current Good Manufacturing Practices (cGMP). Products are tested at ISO 17025 accredited laboratories, and heavy metal testing is routine for every product and raw material before release. See the science.
Are Plexus products tested on animals?
No. Plexus products are not tested on animals.
How should I store my products?
Keep them tightly sealed in a cool, dry place. The fridge or freezer is fine too, though it may cause clumping. Once you mix a Plexus drink, have it within 30 minutes. A few small granules at the bottom of your Slim bottle are part of the ingredients and safe to drink.
How long do products keep?
The usual shelf life for Plexus nutritional products is two years. Use them before the expiration date for the best potency and flavor. The lot number and expiration date are printed together on the bottle or bag.
with other things.
4 questions
Can I take Plexus with my medication?
Please talk to your doctor or healthcare provider first. Plexus can’t give medical advice, and everyone’s health history is different. Take the product label with you so they can see every ingredient.
I am pregnant or nursing. Can I take Plexus?
Talk to your healthcare provider before you take any Plexus product. The same goes for anyone with an allergy, injury, illness or other medical condition.
I have a food allergy. How do I check a product?
Every ingredient is on the label, and any major food allergen defined by the FDA is listed there too. Plexus products do not contain peanuts. Some contain tree nuts or milk (whey), and the label will say so. Plexus also publishes a Product Attribute Sheet with common allergen information for every product. If you have an allergy, check with your doctor first.
Can I take more than one Plexus product?
Many people do. The Gut Health System is three products used together. For any combination, follow each label and check with your healthcare provider, who knows what else you take.
vip membership.
3 questions
What does VIP cost, and when does it renew?
VIP membership is $9.95 to join (usually $19.95) and $19.95 a year to renew. It saves up to 25% on products that show a VIP price. You will see the renewal date before you pay, it is never added for you, and the fee is covered by the 60-day guarantee.
What is the difference between Retail and VIP?
Retail Customers pay the retail price and no membership fee. VIP Customers pay a yearly fee and save up to 25% on products that show a VIP price, monthly deliveries included. VIPs also get a personal link to share Plexus with friends and family.
Can I cancel my VIP membership?
Yes. Call customer care on 480-998-3490. If you cancel within 60 days of your yearly renewal, Plexus refunds that renewal fee. Canceling your account also cancels any monthly deliveries.
monthly delivery.
3 questions
How does monthly delivery work?
Where it is offered, tick “Also deliver this every month” on the product page. It is never ticked for you, and there is no extra discount. Your chosen products then ship automatically each month, and you can have more than one monthly delivery.
Can every product be delivered monthly?
Most can. Limited-time and promotional items can’t be set up for monthly delivery.
How do I change, skip or stop a monthly delivery?
Make changes at least two business days before your next processing date. A delivery can’t be changed or canceled on the day it processes. To postpone or cancel a shipment, send a Customer Service Assistance Form or call 480-998-3490.
orders and shipping.
4 questions
Can I change or cancel an order?
Once an order has been placed, it cannot be modified or canceled. If it is not right for you, the 60-day guarantee still applies.
How long does shipping take?
Orders are fulfilled once payment is complete. Standard shipping in the US takes 3 to 7 business days. Orders placed on a weekend or holiday start fulfillment on the next business day. You will see every shipping option and its cost at checkout, before you pay.
My order has not arrived. What should I do?
Standard orders arrive within 3 to 7 business days of shipping. If 7 business days have passed, send an order status request with the Customer Service Assistance Form.
Something is missing or wrong in my order.
Sorry about that. You can request a replacement with the Customer Service Assistance Form. Have your order number ready.
returns and the guarantee.
4 questions
What if it is not for me?
You have 60 days from the date of purchase to return it for a refund, less the original shipping and a $6 US return fee. Read the guarantee.
How do I ask for a refund?
Fill in the refund request form, or call 480-998-3490 (press 1 for Spanish).
How long does a refund take?
Refunds go back to your original method of payment within 5–7 business days of the return being scanned into UPS possession.
What does the guarantee cover?
One refund per product, and membership fees are included. Retailer packs are refunded as a whole, and some promotional items are excluded. Every refund is less the original shipping and a $6 US return fee. Read the full guarantee.
brand ambassadors.
3 questions
What is a Brand Ambassador?
An independent person who shares Plexus and can help you choose a routine. See ways to join.
What does it cost to become one?
Joining as a Brand Ambassador is $39.95, then $39.95 a year to renew. Compare the ways to join.
Do I have to become a Brand Ambassador to shop?
No. You can shop as a Retail Customer or a VIP Customer. Becoming a Brand Ambassador is a separate choice, and the Join page has the full details.
account and help.
2 questions
How do I reach Plexus customer care?
Call 480-998-3490 (press 1 for Spanish), Monday to Friday 5am–5pm and Saturday 6am–3pm Arizona time, closed Sunday, with extended hours at the end of the month. Or send a Customer Service Assistance Form.
Where can I find step-by-step help?
The Plexus Help Center has articles on orders, shipping, monthly delivery, your account and every product.
nothing matches that yet.
Try a shorter word, like “ship”, “VIP” or “refund”. Or ask a real person: call 480-998-3490 or send a Customer Service Assistance Form.
Customer care
still need a hand.
Customer care can help with orders, returns, monthly deliveries and your account.
- Call
- 480-998-3490Press 1 for Spanish.
- Hours
- Mon–Fri 5am–5pmSat 6am–3pmArizona time. Closed Sunday. Extended hours at the end of the month.
- Write to us
- Customer Service Assistance Form (opens in a new tab)For quick help, send a direct request.
- Refunds
- Refund request form (opens in a new tab)Within 60 days of purchase.
- Help Center
- Step-by-step articles (opens in a new tab)

Not sure where to start?
find my routine.
Three questions. One suggestion, with the reasons in Plexus’s own words.
Take the routine finder